Sakura Arms is a two-player dueling game in which players first choose two of seven megami (Japanese goddesses), each of which has a different keyword that empowers some of their cards. Players then see what the opponent chose before assembling a deck of ten out of 22 cards, with the players choosing cards both to take advantage of their own megami powers and to exploit their opponent's weaknesses. Players then duel to see who will be victorious.

The game uses a single kind of token to represent life, distance, aura (defense), and flare (special energy) based on the zone these tokens occupy. By moving tokens between zones, you attempt to gain the ideal position and set up as many attacks as possible — or be prepared to avoid attacks.